An initiative of the Biomedical Research Council (BMRC) of the Agency for Science, Technology & Research (A*STAR), the SingaporeImmunology Network (SIgN) has setup its premise at the Biopolis, Immunos building (6000sqmt and ~150-200 researchers). SIgN aims to build up a strong program in immunology research in order to improve global understanding of the human immune system, and the translation of this knowledge into medical applications. Learn more about SIgN at http://www.sign.a-star.edu.sg/. 

Starting from March 2012, a postdoctoral research fellow position will be available in Dr. Norman Pavelka’s lab at the Singapore Immunology Network (SIgN) of the Agency of Science, Technology & Research (A*STAR) to study

 

Evolution of fungal pathogens within mouse hosts

 

This lab aims at dissecting (1) the role of host immunity and pathogen evasion in determining the evolution of virulence in fungal pathogens such as Candida albicans and (2) the genomic changes that underlie such evolutionary processes, with a particular emphasis on whole-chromosome and segmental aneuploidies. (See below for relevant literature.) The Pavelka lab is currently funded by the prestigious A*STAR Investigatorship Award. 

References

 

[1]  Rancati G, Pavelka N, Fleharty B, Noll A, Trimble R, Walton K, Perera A, Staehling-Hampton K, Seidel CW, Li R. Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Cell. 2008; 135(5): 879-93.

[2]  Pavelka N, Rancati G, Zhu J, Bradford WD, Saraf A, Florens L, Sanderson BW, Hattem GL, Li R: Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature 2010; 468:321-325.

[3]  Pavelka N, Rancati G, Li R. Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer. Curr Opin Cell Biol 2010.